Endocrine Abstracts

Introduction: Nonfasting duration is much longer than fasting time in a day. Although there is a few reports on the importance of postprandial triacylglycerol (TG) on cardiovascular outcome, TG variation after meal is one of main obstacle of clinical trial. The purpose of this study is to determine effects of a 6-week period of omega-3 fatty acid supplementation on fasting and postprandial TG and metabolic parameters in response to standard test meals.Me...

Background: Current theragnostic techniques for pancreatic neuroendocrine tumors (pNETs) exploit the overexpression of somatostatin receptors (SSTRs) on the cell surface. However, approximately 25% of low-grade and most high-grade pNETs do not express SSTRs, requiring alternative theranostics. Calreticulin (CALR) is a protein linked to reticular calcium homeostasis and immunogenic cell death. Upon sufficient cellular insult, CALR translocates from the endoplasmic reticulum (ER...

Background: Following IHC of CALR, H-scoring was performed by a pathologist. H-scoring was validated by MIF of the same tissue, wherein random-forest machine learning (ML) classifiers were employed to classify cells. ML classifiers were trained to distinguish between pNET cells and tumor stroma using approximately 30% of cells for the respective cell population of interest in each TMA core. Pearson’s correlations were used to evaluate the relationship between H-scoring an...